Re: compatible device? - sCMOS camera Leica DFC9000
USB will generally run slower than CL because of the limited bandwidth but I do not expect any inconvenience otherwise (but I cannot guarantee). Streaming the huge amounts of data the camera produces to the PC is always very demanding to the hardware so you should make sure that there are no unknown processes in the background taking away or blocking resources.
For me the choice is between the convenience of USB against the best possible performance in terms of framerate of CL.